PathVisio Analysis: An Application Targeting the miRNA Network Associated with the p53 Signaling Pathway in Osteosarcoma

MicroRNAs (miRNAs) are small single-stranded, non-coding RNA molecules involved in the pathogenesis and progression of cancer, including osteosarcoma. We aimed to clarify pathways involving miRNAs using new bioinformatics tools. applied WikiPathways PathVisio, two open-source platforms, analyze osteosarcoma miRTar ONCO.IO as integration found 1298 records papers associated with word “miRNA”. In patients good response chemotherapy, miR-92a, miR- 99b, miR-193a-5p, miR-422a expression is increased, while miR-132 decreased. All identified seem be centered on TP53 network. This first application PathVisio determine miRNA MiRNAs have potential become a useful diagnostic prognostic tool management full pathway editor potentiality illustrate biological events, augment graphical elements, elucidate all physical structures interactions standard external database identifiers.